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A High-Throughput, Accurate Mass Approach for Plasma Protein Binding Analysis Using SPE/TOF-MS

An ultafast SPE/TOF/MS method was developed to analyze plasma protein binding assay samples at a rate of 9 sec per sample. This ultrafast, high resolution approach may be useful for the analysis of other in vitro ADME assays

Agilent Technologies

Presenter: Agilent Technologies
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Case Study: The Discovery of Telaprevir (VX-950, Incivek) for the treatment of Hepatitis C

This Case study shows the drug discovery process of Telaprevir for Hepatitis. IT discusses the background of Hepatitis, and the basic information on Hepatitis C, Preclinical studies, Clinical studies, critical findings, timeline to approval and the...

Brain Science Institute NeuroTranslational Drug Discovery Program

Johns Hopkins University

Presenter: Dana Ferraris, Ph.D., M.B.A.
PPT
In Vitro Pharmacokinetics

A lecture discussing In vitro Pharmacokinetics assays including permeability, metabolism, drug-drug interaction, and protein binding.

This is the fifth lecture in a 15-week course, Introduction to Drug Discovery Research, given at Johns Hopkins...

Brain Science Institute NeuroTranslational Drug Discovery Program

Johns Hopkins University

Presenter: Takashi Tsukamoto, Ph.D.
PPT
In Vivo Pharmacokinetics