International Centre for Kinase Profiling
Type:
Screening( in vitro assays, in vitro screens)
Consultants
Description:
Protein kinases are the pharmaceutical industry's most important class of drug target. Nineteen protein kinase inhibitors have been approved for clinical use and over 150 more are undergoing clinical trials of which about 25 are in Phase III. A major challenge in this area is to develop a drug that selectively suppresses the activity of one, or at most a few, of the 500 protein kinases encoded by the human genome.
The MRC Protein Phosphorylation Unit at Dundee pioneered analysis of the selectivity of protein kinase inhibitors by setting up the first service to tackle this problem in 1998. This procedure, termed "kinase profiling" proved to be of great help to the pharmaceutical industry, speeding up the development of specific protein kinase inhibitors with therapeutic potential. Since then many biotechnology companies, as well as academic drug discovery centres, have entered this area, and also need access to "kinase profiling" services at an affordable price.
Working with leading experts from Pharma, we have implemented the industry level of standard operating procedures that guide all our services. Since 1998, we have collaborated with 8 different large pharmaceutical companies including Pfizer, GlaxoSmithKline, Boehringer-Ingelheim, Merck-Serono, Astrazeneca, Janssen Pharmaceutica NV, Novo-Nordisk and Merck & Co.
Our service is available to anyone that wishes to use it and our panel of protein kinases has now increased in size to 140. We have also launched a new lipid kinase profiling service in July 2012. The information in this website explains how "kinase profiling" is carried out and how it can be accessed by interested parties.
The ICKP is housed within the MRC Protein Phosphorylation & Ubiquitylation Unit, home to the worlds leading experts on kinases and phosphorylation. if further guidance is needed -- if you are new to this field or would just like advice from another scientist -- we can help you liaise with a resident expert.
City: Dundee
State: Scotland
Contact Person: kinase-screen@dundee.ac.uk
Contact email: kinase-screen@dundee.ac.uk
Contact Number: +44-(0)1382-388-056
Announcement Title: International Centre for Kinase Profiling
