Creative Animodel
Type:
Pre-Clinical( Toxicology, Animal Testing)
Clinical
Description:
http://www.creative-animodel.com/Animal-Model-Development/Animal-Models-of-Disease.html
Tags:animal model,oncology,CNS
Replications and Applications of Animal Model with Disease
Replication of animal disease model, is using manual methods, which in certain animal pathogenic factors (physical, chemical, biological effects) animal tissue, organ damages that there appear some similar diseases to humans like metabolic function or the morphological structure changes. Through such replication method,it provides a theoretical basis to study human diseases, its development, treatment, and prevent human diseases.
Replication methods of induced animal model are produced with nothing more than the use of biological, physical, chemical and environmental factors to the animal.
Biological factors include bacteria, viruses, parasites, cell, biological toxins, hormones and other pathogens, which were inoculated in animal for disease.
Physical factors are in many aspects. For example, under the action of mechanical force, there produce all kinds of traumatic brain injuries, fracture model , pressure change altitude sickness, diving disease; Burn and frostbite are caused by temperature; radiation can copy each type of radiation sickness, causing the immune function inhibited or induced Spragae-Dawley rat breast cancer; Epilepsy model induced by photic stimulation.
Chemical factors can directly or indirectly (through metabolites) cause harmful effects on the body. Such as the use of a variety of chemical carcinogen induces tumors, the use a variety of chemicals or gas induces a variety of poisoning disease or the use of strong base, strong acid can cause skin burns.
Oncology Models. The number of oncology models occupies the first place in the induced animal model.The general method is using carcinogenic substances through the oral, injection, painting and other ways to make animal have tumour. There are a lot of reports to tumours which can induce animal , such as murine leukemia virus (MLV), avian leukosis virus (ALV) and feline leukemia virus (FLV), which can cause rat, chicken and feline get leukemia.
Central Nervous System Models (CNS Models).
Brain tumor model;
Stroke model;
Epilepsy model;
Brain edema model.
Respiratory Models.
Chronic bronchial pneumonia model;
Pulmonary emphysema model;
The model of pulmonary edema;
Bronchial spasm, asthma model;
In addition, dogs can induce experimental asthma exposed to the extract of toxocaracanis, ascaris suum or hybrid seed two times a week.
Experimental silicosis model.
The diabetic model.Method of diabetic model is the injection of hyperglycemic factor.All or most of the pancreas are operated excision, with alloxan destructing pancreatic beta cells, resulting in pancreatic diabetes. Then to inject phloridzin to block the resorption renal tubular to glucose and destruct esterase to form obstacle during phosphorylation and dephosphorylation.
Alloxan animal model is a better replicated method of studying human diabetes. Its experimental diabetes is similar to human diabetes. There may produce the derivative metabolism in vivo. Pancreatic exocrine portion is not damaged, almost all commonly used experimental animals can be used for experimental study.
City: Shirley
State: New York
Contact Person: Andrea
Contact email: wangyizhuss@gmail.com
Contact Number: 13658092493
