Education Material

Case Study: The Discovery of Telaprevir (VX-950, Incivek) for the treatment of Hepatitis C

This Case study shows the drug discovery process of Telaprevir for Hepatitis. IT discusses the background of Hepatitis, and the basic information on Hepatitis C, Preclinical studies, Clinical studies, critical findings, timeline to approval and the...

CNS Medicinal Chemistry: Introduction and a Case Study – GlyT1

This lecture will provide an overview of the drug discovery process with specific attention being paid to the role of medicinal chemistry, and key issues for the CNS disease-focused medicinal chemist (Lipinski’s rules, CNS penetration, transporter...

Drug-Like Properties and Druggable Targets

A lecture discussing the concept of drug-like molecular properties, druggable targets, and chemical space.

This is the second lecture in a 15-week course, Introduction to Drug Discovery Research, given at Johns Hopkins University School of Medicine,...

Formulation and Route of Administration

In order to exert the desired effect in a proof-of-concept animal study, a drug molecule or development candidate first of all needs to be bioavailable and lack of solubility therefore often poses the first barrier to successful translation a...

Hit to Lead to Candidate

Once a drug target has been identified and assays developed, hits (compounds with confirmed activity at the target) are obtained from many sources - often from high-throughput screening. Drug discovery scientists investigate the hits by obtaining or...

In Vitro Pharmacology I

A lecture discussing the general background of In Vitro Pharmacology and the two different target-based assays: enzymatic and Receptor.

This is the third lecture in a 15-week course, Introduction to Drug Discovery Research, given at Johns Hopkins...

In Vitro Pharmacology II

A lecture discussing Phenotype-Based Assays, High Throughput Screening, and Weeding out undesirable hits in In Vitro Pharmacology.

This is the fourth lecture in a 15-week course, Introduction to Drug Discovery Research, given at Johns Hopkins...

Lead Optimization

A lecture on hit to lead and lead optimization.

This is the tenth lecture in a 15-week course, Introduction to Drug Discovery Research, given at Johns Hopkins University School of Medicine, discussing the various aspects of the drug discovery...

The Small Molecule Discovery Center

This presentation introduces the Small Molecule Discovery Center at UCSF, and describes the center’s goals, philosophy, and examples of projects. Several different approaches to interacting with pharmaceutical companies are also summarized.